in World News FRIGHTENING TRUTH: Airborne mRNA Vaccines are being created that can be delivered straight into the Lungs without the need for Injection
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Researchers have developed an airborne mRNA vaccine offering a vehicle by which to rapidly vaccinate the masses without their knowledge or consent.
A team from Yale University has developed a new airborne method for delivering mRNA right to your lungs. The method has also been used to vaccinate mice intranasally, “opening the door for human testing in the near future.”
While scientists may celebrate this invention as a convenient method to vaccinate large populations, skeptics raise obvious concerns about the potential misuse of an airborne vaccine, including the possibility of covert bioenhancements a concept that has previously been suggested in academic literature. (source).
Researchers have developed an airborne mRNA vaccine offering a vehicle by which to rapidly vaccinate the masses without their knowledge or consent.
A team from Yale University has developed a new airborne method for delivering mRNA right to your lungs. The method has also been used to vaccinate mice intranasally, “opening the door for human testing in the near future.”
The Study: Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination
In a research conducted on mice, scientists from Yale University developed polymer nanoparticles to encapsulate mRNA, transforming it into an inhalable form for delivery to the lungs. Courtney Malo, who serves as an editor at Science Translational Medicine, the publication that featured the study, explained,
“The ability to efficiently deliver mRNA to the lung would have applications for vaccine development, gene therapy, and more. Here, Suberi et al. showed that such mRNA delivery can be accomplished by encapsulating mRNAs of interest within optimized poly(amine-co-ester) polyplexes [nanoparticles].
Polyplex-delivered mRNAs were efficiently translated into protein in the lungs of mice with limited evidence of toxicity. This platform was successfully applied as an intranasal SARS-CoV-2 vaccine, eliciting robust immune responses that conferred protection against subsequent viral challenge.
These results highlight the potential of this delivery system for vaccine applications and beyond.“
The team, which was led by cellular and molecular physiologist Mark Saltzman, claims that the inhalable mRNA vaccine “successfully protected against “SARS-CoV-2“, and that it “opens the door to delivering other messenger RNA (mRNA) therapeutics for gene replacement therapy and other treatments in the lungs.”(source)
For the study, mice received two intranasal doses of nanoparticles carrying mRNA COVID-19 vaccines, which proved to be effective in the animals. In the past, lung-targeted mRNA therapies had trouble making it into the cells necessary to express the encoded protein, known as poor transfection efficiency (source).
“The Saltzman group got around this hurdle in part by using a nanoparticle made from poly(amine-co-ester) polyplexes, or PACE, a biocompatible and highly customizable polymer,” a Yale University news release explained. In a previous study, Saltzman had tried a “prime and spike” system to deliver COVID-19 shots, which involved injecting mRNA shots into a muscle, then spraying spike proteins into the nose.
It turned out the injection portion may be unnecessary, and Saltzman has high hopes for the airborne delivery method, beyond vaccines: (source).